Your Recovery Begins at American Addiction Centers
Home » Opioid Detox Symptoms, Side Effects & Timeline
Specific Opioids Detox Guides

Opioids include heroin and prescription painkillers, such as fentanyl, oxycodone, hydrocodone, codeine, morphine, and many others. These drugs are extremely addictive, and the painful withdrawal symptoms often lead to relapse, which is why treatment is so important.

Opioid Detox Symptoms, Side Effects & Timeline

Ready to make a change?
Check to see if your insurance covers treatment at an American Addiction Centers facility.
Verify Insurance Benefits

Opioid pills spilled on a table

Opioid drugs are either partial modifications of these naturally occurring substances (semi-synthetic) or are completely artificial (fully synthetic) 1. Many opioids have legitimate, medical uses like alleviating various types of pain, managing cough, and treating diarrhea. Opioid medications are widely prescribed with about 207 million total prescriptions written in 2013, according to the National Institute on Drug Abuse (NIDA).2

Opioid misuse has become a national epidemic, with over 46,000 people dying from an opioid overdose in 2017. The numbers we see every year reveal how big of a problem opioid can be.

Is opioid abuse a problem for you? If it is, know that you are not alone and that help is available. Call one of our admissions navigators at 1-888-509-8965 Who Answers? so they can provide the information and support that you need as you begin your journey away from opioid misuse and toward sobriety.

Types of Prescription Opioids

  • Hydrocodone: Vicodin, Norco, and Zohydro1.
  • Oxycodone: OxyContin, Percocet, and Percodan.
  • Hydromorphone: Dilaudid.
  • Morphine.
  • Codeine.
  • Fentanyl.
  • Methadone.

Considering Detox

Doctor holding clipboard
Before you make a decision to forego drug detox, it is worth taking a moment to understand what detoxification symptoms are and how they work. Doing this may help you make a more informed decision about the next step in your recovery process. Read More

These prescription medications all carry the risk of opioid dependency, especially when misused 1.The opioid class of substances also includes heroin, which is an illicit drug synthesized from morphine 1. The Drug Enforcement Administration (DEA) considers all opioids to be controlled substances. Heroin is Schedule I with no recognized medical purpose and many of the opioid painkillers are Schedule II, meaning they have medicinal uses but carry a high risk of abuse 10.

Opioid abuse is a worldwide problem with as many as 36 million people abusing these substances 2. In the U.S. alone 2:

  • More than 2 million people have substance use disorders linked to prescription opioids.
  • Nearly 500,000 people are addicted to heroin.

All opioids can have a lasting negative impact when abused, but these substances also result in very distressing effects when the user quits. Opioid withdrawal symptoms can be erratic, yet quite severe as they impact numerous aspects of a person’s physical and mental health.

What Are The Symptoms of Opioid Withdrawal?

Though each person’s experience during opioid withdrawal will be quite different, many opioid detox symptoms are similar across substances and include 5,6,7:

  • Mental health symptoms, such as depression and anxiety.
  • Gastrointestinal symptoms, such as nausea, vomiting, and diarrhea.
  • Fever.
  • Sweating.
  • Goose bumps.
  • Watery eyes and runny nose.
  • Muscle aches, cramps, and spasms.
  • Yawning.
  • Dilated pupils.
  • Disturbed sleep patterns.

If you worry that you or a loved one is at risk of opioid withdrawal symptoms, seeking detox treatment is a safe decision.

Opioid Detoxification

The individual differences will dictate many aspects of withdrawal and detox, including the timeline and intensity of symptoms, be they acute or protracted in nature. Detoxification (drug detox) is the term used to describe the process of the body clearing a drug from the system 6. The opioid detox timeline is influenced by many factors related to patterns of use and other individual characteristics including 6:

  • The specific opioid of abuse.
  • The dose, frequency, and route of administration.
  • The duration of use.
  • If the opioid was abused concurrently with other substances (i.e., polysubstance abuse).
  • The individual’s physical and mental health status.
  • The individual’s unique physiology.

Withdrawal symptoms from short-acting opioids, like heroin, present 6 to 12 hours after last use and will last for 5-7 days overall 5. Long-acting opioids, like methadone, will have delayed withdrawal symptoms and longer total durations with symptoms arising between 2-4 days after the most recent dose and possibly lasting for 3 weeks 5,6,7.

Following any period of acute detox, some people in recovery from opioid dependence may experience delayed or extended withdrawal symptoms lasting 6 months as part of a phenomenon termed protracted withdrawal or post-acute withdrawal syndrome (PAWS) with symptoms like 8:

  • Depression.
  • Emotional numbing or blunting.
  • Anxiety.
  • Fatigue.
  • Irritability.

Again, the individual differences will dictate many aspects of withdrawal and detox, including the timeline and intensity of symptoms of opioid use, be they acute or protracted in nature.

Effects of Opioid Detox

Although opioid withdrawal symptoms are not typically life-threatening, they can still produce significant medical and mental health complications, especially when left untreated 6,7. The effects of opioid withdrawal include 5,6,7:

  • Relapse/overdose: The reduced tolerance for opioids during recovery paired with strong cravings can result in relapses, overdose, and possibly death.
  • Dehydration/aspiration: The tendency to vomit, sweat, and have diarrhea results in dehydration. While vomiting, some will inhale and choke causing aspiration of stomach contents into lungs.
  • Pain sensitivity: Without the opioid in the body, the individual will have a decreased tolerance for pain and discomfort.
  • Cardiac distress: Opioid withdrawal can add stress to a person’s cardiovascular health by increasing blood pressure and heart rate.
  • Depression/anxiety: With increased mental health stress during drug detox, people regularly report higher levels of depression and anxiety.

Opioid Dependence Treatment Options

Attempting to detox alone can cause unnecessary pain and distress. Professional detox options specialize in managing opioid withdrawal symptoms and cravings while improving comfort and safety 6,9. Different drug detox options are available at varying levels of need but are commonly separated into 6,9:

Man in inpatient treatment counseling

  • Inpatient opioid treatment: Any treatment that allows the client to live at the facility during treatment is labeled inpatient/residential. The term “inpatient” sometimes applies to more intense, short-term programs that are typically conducted in hospital settings. Residential programs may be longer in duration and more closely resemble a home setting.
  • Outpatient opioid treatment: Treatments that allow the individual to continue with daily life while attending treatment during the day are considered outpatient. These programs are best for people with relatively less severe addictions and stronger support systems in place. Outpatient detox treatment occurs in many locations like doctor’s offices and community health centers.

Opioid withdrawal medication may be used to mitigate unwanted withdrawal symptoms and alleviate opioid cravings. Medication-assisted treatment options for opioid withdrawal include 11:

  • Suboxone: A combination of naloxone, an opioid antagonist, and buprenorphine, a partial opioid agonist, designed to prevent diversion and abuse of buprenorphine. This opioid withdrawal medication alleviates cravings and detox symptoms without producing a euphoric rush.
  • Methadone: A full opioid agonist that reduces opioid withdrawal symptoms, eases cravings, doesn’t elicit a high.
  • Naltrexone: An opioid antagonist that blocks the desirable effects of opioids to prevent abuse.

As mentioned, opioid detox programs are short-term. They do not serve as a substitution for comprehensive opioid use disorder treatment. Following detox, it is important that an individual in recovery pursues opioid addiction treatment to promote increased success and longer periods of abstinence 9.


  1. National Institute on Drug Abuse for Teens. (2016). Prescription Pain Medications: Opioids.
  2. National Institute on Drug Abuse. (2014). America’s Addiction to Opioids: Heroin and Prescription Drug Abuse.
  3. Drug Enforcement Administration. (n.d.). Narcotics.
  4. Medscape. (2016). Withdrawal Syndromes.
  5. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
  6. Substance Abuse and Mental Health Services Administration. (2015). Detoxification and Substance Abuse Treatment.
  7. World Health Organization. (2009). Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Setting.
  8. Substance Abuse and Mental Health Services Administration. (2010). Protracted Withdrawal.
  9. National Institute on Drug Abuse. (2012). Principles of Drug Addiction Treatment: A Research-Based Guide.
  10. Drug Enforcement Administration (2006). Practitioner’s Manual: An Informational Outline of the Controlled Substances Act.
  11. National Institute on Drug Abuse. (2014). What are the treatments for heroin addiction?

You Only Get One Body

Get Clean & Sober With Detox